Age-related changes of metallothionein 1/2 and metallothionein 3 expression in rat brain
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چکیده
منابع مشابه
Metallothionein in Brain Disorders
Metallothioneins are a family of proteins which are able to bind metals intracellularly, so their main function is to regulate the cellular metabolism of essential metals. There are 4 major isoforms of MTs (I-IV), three of which have been localized in the central nervous system. MT-I and MT-II have been localized in the spinal cord and brain, mainly in astrocytes, whereas MT-III has been found ...
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PURPOSE To analyze the expression of metallothionein in neovascular membranes in patients with age-related macular degeneration (AMD) and to compare the findings in patients with proliferative diabetic retinopathy and proliferative vitreoretinopathy with findings in normal retinal pigment epithelial (RPE) cells. METHODS Semiquantitative reverse transcriptase-polymerase chain reaction and immu...
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BACKGROUND Metallothionein (MT) is a small, cysteine-rich, metal-binding protein that plays an important role in protecting against toxicity of heavy metal and chemicals. This study was aimed to define diurnal and sex variation of MT in mice. METHODS Adult mice were maintained in light- and temperature-controlled facilities for 2 weeks with light on at 8:00 and light off at 20:00. The blood, ...
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Metallothioneins are encoded by a family of genes that are induced by inorganic mercury. Despite the well-characterized acute response of metallothionein (MT) genes in the kidneys and liver after a single exposure to inorganic mercury, relatively little is known about the activity of these genes and the content of MT protein during prolonged periods after exposure. Rats treated with inorganic m...
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AIM To investigate the expression of metallothioneins (MTs), which were recently thought to have close relationship with tumors, in human hepatocellular carcinoma. METHODS Histological specimens of 35 cases of primary human hepatocellular carcinoma with para-neoplastic liver tissue and 5 cases of normal liver were stained for MTs with monoclonal mouse anti-MTs serum (E9) by the immunohistoche...
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ژورنال
عنوان ژورنال: Comptes Rendus Biologies
سال: 2017
ISSN: 1631-0691
DOI: 10.1016/j.crvi.2016.11.003